- Research of the oldest traces of life on Earth: what morphological traces, molecular, isotopic or biochemical signs of life? How do we define the traces bioinduced or biocontrolled ? What are the unequivocally criteria (or signs) to distinguish inert (mineral or organic) from living (organic)?
- The interpretation of the evidences in their context: how to search for optimal indices of life whatever the analysis supports (rock, grains, ...)
- The search for signs of life elsewhere, or present or past on extraterrestrial bodies: should we analyze specimens or samples (representative)? How to reliably detect a biomass (viable, dormant or fossilized) or an evidence of life? How quickly remove any ambiguity about the origin of the observed body (biotic / abiotic contamination)? Sensitivity and resolution of the measurement chains.